Can also happen because of temperature change, drop, causing pressure drop. The only way to know for sure that it is indeed a "leak" is to submerge the system in water and watching for consistent bubble leak.
Well, that is not totally correct.
If the pressure continues to go down day after day (for several days or more), it can only be explained by a leak.
The pressure drop as a function of temperature drop (often referred to as Charles’s law) is part of what is commonly known as ideal gas law. Ideal gas law is one of the thermodynamic processes that is 100% reversible.
In other words, if you have a truly closed gas system (at constant volume), the pressure would go down when the temperature goes down, but it will also go back up when the temperature goes back up.
This up and down process is completely reversible and the relationship between pressure and temperature stays constant. This process and relationship is so repeatable that we have made some dial indicating thermometers that read temperature, but they are actually driven by the gas pressure.
I have been using this method for enough decades that I have a fairly good “empirical feel “ for the bubbles size and rate that I would expect to see. I have also done plenty bubble check to check for leaks. I actually have a high pressure hose that I can attach a first stage and dunk them in water without having to move a scuba tank.
BTW, some of the leak rates I am referring to can be as low as a bubble per minute or less (depending on location).
At one time I actually did some rough calculation of leak rates.
Some leaks should be located and repaired because they will get worse with time, but there are some minute leaks that can be easily tolerated.