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@ DocV, do you have anything more specific on the effects of any of his meds on CBF?DDM
Hey DDM,
I believe the research you cited reported that depressed subjects who improved in response to a trial of citalopram (e.g., Celexa) had a higher regional cerebral blood flow (rCBF) in the posterior cingulate area prior to treatment than did those who did not respond. However, after 4 weeks on the drug those who improved actually showed a decrease in rCBF in that cortical region. Do I have this correct?
If so, the finding is consistent with other research demonstrating that those who improved with the antidepressants nortriptyline (e.g., Pamelor, Aventyl) or sertraline (e.g., Zoloft) showed reduced (rCBF) in frontal regions following a month or two of treatment.
As you note, Celexa, like Lexapro (the "next generation" Celexa) and Zoloft, is a selective serotonin reuptake inhibitor (SSRI).
Regards,
Doc
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