Prozac (fluoxetine) may have neuroprotective effects in Type II DCS.+

[DocVikingo]

[I get regular inquiries concerning diving on antidepressants. For a broader treatment of the issue of scuba with affective disorder see --> Depression & Diving: Part II. Making the call on recreational diving ( Depression and Diving, ).


Protective Effects of Fluoxetine on Decompression Sickness in Mice

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[Duke Dive Medicine]

50 mg/kg? Holy extrapyramidal symptoms, Batman.

 

[divad]

50 mg/kg? Holy extrapyramidal symptoms, Batman.

Yeah, what he said.

 

[JohnN]

50 mg/kg? Holy extrapyramidal symptoms, Batman.

A quick internet search says 80 mg is the maximum dose for an adult. . . looks like the dosage for Type II DCS would cure a lot of other problems

 

[gert7to3]

If you took that much, the overdose would simply distract everyone form worrying about the DCS. That said, I believe Prozac is used for concussions.

 

[DocVikingo]

50 mg/kg? Holy extrapyramidal symptoms, Batman.

LOL.

Obviously pharmacodynamics in mice v humans are not always parallel. Also obvious is the difficulty of performing such an experiment on humans.

Per the authors, "We opted to use a high dose of fluoxetine based on previous research in a mouse model of ischemia [18], [20].

18. Jin Y, Lim CM, Kim SW, Park JY, Seo JS, et al. (2009) Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. Brain Res 1281: 108–116. [Fluoxetine attenuates kainic acid-induced neuronal... [Brain Res. 2009] - PubMed - NCBI]

20. Taguchi N, Nakayama S, Tanaka M (2011) Fluoxetine has neuroprotective effects after cardiac arrest and cardiopulmonary resuscitation in mouse. Resuscitation 83: 652–656. [Fluoxetine has neuroprotective effects after c... [Resuscitation. 2012] - PubMed - NCBI]

Cheers,

DocV

---------- Post added April 22nd, 2013 at 09:36 AM ----------

If you took that much, the overdose would simply distract everyone form worrying about the DCS. That said, I believe Prozac is used for concussions.

Fluoxetine is not a first line drug for treating concussion. It may be used as an adjunct in treating post-concussion depression, an affective abnormality that occurs in perhaps 25% of those with post-concussion syndrome.

Regards,

DocVikingo

 

[TSandM]

What would be really interesting about the study is not the idea that we could use Prozac in humans, but that the mechanism by which it is protective would be an interesting one to understand, to see if that understanding could be applied to a more effective approach in humans. Interesting study, and thank you, Doc, for posting it.

 

[Duke Dive Medicine]

50 mg/kg? Holy extrapyramidal symptoms, Batman.

What would be really interesting about the study is not the idea that we could use Prozac in humans, but that the mechanism by which it is protective would be an interesting one to understand, to see if that understanding could be applied to a more effective approach in humans. Interesting study, and thank you, Doc, for posting it.

There you go, trumping my rapier wit with insight