I think a LOT of generalizations abound about how things like iTTL, eTTL, optical slave sensors, and flash technology work. What people need to understand is that this is all based on how each manufacture has engineered a solution, and that is likely not even narrow enough. Name the flash make and model, and then MAYBE we can begin to discuss if it works well in mode X. Since not ONE of us are working on these designs, and they are closely guarded by first the OEM, and then by the third party manufactures like Ike and Inon, I would not expect that any of us has an exact understand of what goes on behind the covers.
Case in point the Inon D2000 uses the camera's preflash to determine the proper flash exposure. Preflash has meaning. In fact preflash is communication in many camera's. Nikon uses their preflash to communicate the camera's exposure settings, subject distance, and other information to control remote wireless flashes.
Inon has come up with a way they think works well with the D2000 to use the preflash as an exposure reference to control their flash. Does this work well? I don't know as I don't own that flash, but obviously Larry C who owns this system feels it does.
HERE is a link that leads to an explanation of Inon STTL technology, and they seem damn proud of it, so my bet, it works better than people may expect!
I think one statement that is generally true is that if in doubt, set the strobe using a manual method and use experience, and a histogram to judge if that is producing the desired output!
However just like we rely on TTL exposure to determine our camera setting if that be manual, Aperture, Shutter whatever, flash manufactures are going to continue to engineer solutions so we will have the same confidence when using a flash. Topside it is already a reality, but UW strobe manufactures are a bit behind, but catching up quickly.