I'm 6' 3", 210 pounds, and have also been using nitrox since the 90s. I've never noticed any difference. I used to dive deep air with double steel 120s and two 40 cu ft deco bottles. Moving all of that through water is a lot of work. I always made incredibly slow ascents, especially the last fifteen feet, and was never too tired to pull my tanks back on board as well as my buddies' tanks and the anchor/chain. One of my buddies used to call me freakishly strong. For the past ten years, most of my diving has been using nitrox as deep as 40 meters. I understand how the placebo effect works, therefore I don't notice any reduction in fatigue. I dive steel 130s. After a day of diving, I carry my tanks as well as Merry's from the boat to the car, plus clean the boat. Diving is a lot of work. If it caused noticeable fatigue, I'd probably switch to lighter tanks.