Not too long ago someone in Cave country (N.Fl.), was/is injured in because of the isolator (sort of) Since I don't have first hand knowledge I hesitate to speak too authoritatively however I can speak second hand. The argument goes that had there not been an isolator than the accident couldn't/wouldn't have happened. The isolator wasn't as much of the problem as other factors, but nonetheless no isolator, no accident.
I certainly agree with Bobby, in that if I was solo I think an isolator could come in handy(to say the least). The diving some of us are doing dictates self reliance. In my case my wife(also a scuba instructor) has very kindly and politely asked me NOT to cave dive solo, OW and wreck is another story. (I know, I know-what's the difference, but that's another story)
So as I have stated I will PROBABLY go to a straight bar for cave, and keep a set of dbls with an isolator for wreck and deep.
As far as a manifold vs independent dbls, that seems to be another option that makes scuba so damn much fun, choices-options-alternatives-more toys to play with.