I'm not sure science understands very well whether the effects of gas narcosis, CO2 retention, and fatigue (did I miss any?) are inter-related or whether some are independent of others. But they all seem to be factors in whether you are impaired. The term "narcosis" is commonly used to refer to the anesthetic effect (Meyer-Overton hypothesis), but maybe it's presently impossible to separate out the various "impairment" factors.
In other words, I don't know the answer to the OP's question.
In other words, I don't know the answer to the OP's question.