The G250 HP is definitely a workhorse and a great reg. It has a larger diaphram, which equates to a greater surface area for water pressure to act upon to start the initial inhalation process. This is suppose to contribute towards reduced inhalation effort. It is my understanding that regs with smaller housings and diaphrams are tweaked mechanically internally with different levers, poppet designs, air passages, etc. in order to accomplish the same desired results. In other words, older designs = more simple, and newer designs = not as simple, but hopefully with comparable (or better depending on the reg) performance. Please take note...with regs, newer may not always be better. Check them all out.
Many divers buy the S550 because it's smaller and may reduce jaw fatigue. Please note I said "may." Some like the S600 because of the adjustment knob option, although once the knob is set, many divers don't constantly readjust it. With the S600, the diver can make it breathe as easily or not so easily as desired.
I have used the G250 HP on occasion, but have never used the S550. I have more experience with the S600, so that is the only one I can speak about from real experience. I was very pleased with it's performance and size.
Regarding the X650, I have owned two of them in the past, but was not very impressed. There have been factory upgrades to the X650, but in my opinion, I still don't think they've got it right. It is based on the older D300/D350/D400 series reg designs, which are top-notch performers, and which are the ones I currently dive with. The basic design of the X650 is a good one, with good intentions, but I think there is still some work to be done.
Some people will argue that the reg they use is the very best, but you may just want to rent different ones before you buy. As mentioned above, try a search on regulator threads that were posted by DA Aquamaster. He is a very knowledgable Scubapro technician who can give you many angles to consider, from history of regs, to use and serviceability.
Regardless of your decision, I don't think you will go wrong with Scubapro's time-proven and bullet-proof regs. I think the MK25 is a great choice as a 1st stage, so you're already on your way to owning a great reg set.
Good luck!