While I have not read this whole thread, it appears that there may be a lot of misinformation presented as fact about oxygen and its narcotic ability. It appears that this is a classic example of internet information (or misinformation) being broadcast. I would talk to DAN about this, and seek the scientific studies on this situation, rather than relying upon any information here.
Hello,
Prescient words John. There seems to be a general sense on this thread that oxygen has been demonstrated to be as narcotic as nitrogen. This is not true. It is a complicated matter and still debated in the scientific literature. Some older papers did suggest narcotic effects by oxygen, but to my knowledge only one paper using modern experimental techniques has raised that possibility,
though the study was not designed to isolate the effects of oxygen alone, and the measured effect may have been hyperexcitability rather than narcosis. [1]
In contrast, more recent studies have found that oxygen enhances cognitive function at surface pressure [2] and that nitrox produces less cognitive impairment, and may actually enhance cognitive function at depth. I
n one fascinating study this even seemed to apply to the elevated PO2 in air on arrival at 30msw equivalent in a dry recompression chamber, with nitrox being even better. [3] That positive effect was attributed to excitability / arousal.
More recently our group (specifically, one of my PhD students - now a post doc, Dr Xavier Vrijdag) has tried to hone in on the effects of individual gases using quantitative electroencephalogram (EEG) analyses. Xavier developed an analysis technique that demonstrated dose dependent EEG change during hyperbaric nitrogen exposures, but not helium exposures. [4] This represents
the first EEG algorithm that appears capable of quantifying nitrogen narcosis.
The latest study in this series applied that same algorithm to divers exposed to hyperbaric oxygen at 142 and 284 kPa (1.4 and 2.8 ATA - representing typical maximum exposures to oxygen in diving and hyperbaric chambers respectively). Oxygen at these pressures did not cause the same EEG changes (or changes in psychometric test performance) as hyperbaric nitrogen, suggesting that oxygen is not narcotic, or at least not in the same way as nitrogen. It did cause EEG changes suggestive of hyper-excitability. Those results have just been accepted for publication [5] and as soon as the paper is available I will post a link.
So, overall, I would characterise the modern literature as trending away from attributing a nitrogen-equivalent narcotic effect to oxygen. Oxygen may even enhance cognitive performance. However, work in this space continues. We are also in the middle of a series of experiments aiming to evaluate how CO2 fits into the mix.
Simon M
References:
1. Freiberger JJ, Derrick BJ, Natoli MJ, Akushevich I, Schinazi EA, Parker C, Stolp BW, Bennett PB, Vann RD, Dunworth SAS, Moon RE. Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers.
J Appl Physiol 121: 953–964, 2016.
2. Scholey AB, Moss MC, Neave N, Wesnes K. Cognitive performance, hyperoxia, and heart rate following oxygen administration in healthy young adults.
Physiol Behav 67: 783–789, 1999.
3. Germonpré P, Balestra C, Hemelryck W, Buzzacott P, Lafère P. Objective vs. Subjective Evaluation of Cognitive Performance During 0.4-MPa Dives Breathing Air or Nitrox.
Aerosp Med Hum Perform 88: 469–475, 2017.
4. Vrijdag XCE, van Waart H, Pullon RM, Sames C, Mitchell SJ, Sleigh JW. EEG functional connectivity is sensitive for nitrogen narcosis at 608 kPa.
Sci Rep 12: 4880, 2022.
5. Vrijdag XCE, van Waart H, Sames C, Mitchell SJ, Sleigh JW. Does hyperbaric oxygen cause narcosis or hyperexcitability? A quantitative EEG analysis.
Physiological Rep. In press, 2022