Docmartin, is flexibility.
I dive a DUE 450. The material is slightly 'stiffer' than the DUE 350. Based on my comparison, the hypercompressed neoprene which is proprietary to DUI is stiffer still.
I normally dive my drysuit with minimum argon inside, just enough to take the squeeze off.
During my DIRf the trade-off became apparent: Keep enough argon in the suit to ensure flexibility to reach/turn the isolater valve, the gas shifts around inside the suit (in turn causing trim problems). Reduce gas volume inside the suit to prevent gas displacement variance, the thicker material then restricts or constrains rapid, secure acquisition and manipulation of, especially, the isolater valve.
When you add potential flexibility issues to the potential for bouyancy variance inherent to the hypercompressed neoprene, the conclusion is simply that such suits are not optimal.
Doesn't mean they can't be used. Means they are not optimal.
Optimal is a thin shell suit which can be used with 400 gr thinsulate undergarment, which offers maximum flexibility with minimum argon inside suit.
FWIW.
Doc
PS Also FWIW, I concur with scubajim1 above. If you have the chance to take a DIRf, I recommend you do so. Eye-opening experience...