" I'm pretty certain that it depends on your camera/strobe combo. I use Inons (Z240s, but there's no reason to assume that the S2000s should behave differently) with my Olympus OM-D, and TTL auto has been as painless as it can be. OTOH, I've heard others having issues with the same strobes, but paired to another camera brand."
It isn't a compatibility problem between them but rather the fact that Sealife uses a very different tray/arm system than anyone else and their lights and strobes are designed for that system. You can (and I did) fix up a Nauticam tray to the Sealife housing and further set up both S&S and Inon strobes using the fiber adapter from Sealife but it took half a day of fiddling and finding the right size stainless steel machine screws.
Cheers
Bill