Back in my freediving days, I would routinely take two aspirin about an hour prior to diving. The effects I was looking for was different from a belief that it helped prevent DCS.
With the aspirin, I was able to dive longer, without ear discomfort from the constant pressurization and depressurization of the ears. The aspirin DIDN'T prevent ear squeeze. Instead, it prolonged the time until the eardrum and eustatian tubes become sore or inflammed. It worked quite well, IMHO.
The other effect was once reseached by the University of Miami Medical School. I've looked for the article with no success. Taking aspirin at least an hour before a dive and then every 4-6 hours thereafter dramatically reduced sunburn. The anti-inflammatory effect of the aspirin reduced the damage of the cumulative effects of wind, sun, salt--all, of which contribute to the "burn". It must be noted that no mention was made of a "protective effect" to UV exposure or its cumulative effects. ASPIRIN DOES NOT PREVENT SKIN CANCER. The aspirin easily extended the time on the boat before sunburn began to be noticed. In most cases little or no burn occurred to ME (I have a dark complexion) on dives after the winter, when my tan had faded. In lighter skinned persons, it works but not to the extent it does for a darker complexion. Even with a tan, the skin is still at the mercy of salt burn and wind burn--on the lips, upper parts of the ears, etc. I rarely had any problem--even in near the Equator when I used aspirin.
Since I cannot produce the scientific information I make no "statement of fact or accuracy". In my experience premedication with aspirin was helpful--anecdotal info only.
The reasoning behind the use of aspirin (and I would expect other NSAIDs) is that it reduces or delays the inflammatory response, which can be injurious in itself.
For people who are not sensitive to aspirin, ibuprofen, or naproxen, etc. have no asthmatic episodes to these drugs or are NOT allergic to sulfonamides, they are useful. In dentistry, Dolobid 500 mg is sometimes prescribed prior to wisdom tooth extractions (12 hours prior). A significant reduction of "dry socket" has been noted and often these patients did not require narcotic prescription following the surgery. It has little effect on platelets. In fact, aspirin is the drug most likely to cause bleeding. This fact has been recently noted in studies of Vioxx and Celebrex. In patients taking these drugs for arthritis instead of aspirin, an increase in heart attacks and strokes were noted. The simple reason was that they no longer had "thinned" their blood with aspirin--which had been previously been taken for arthritis. Switching to the newer drugs produced more pain relief to their arthritis but provided little or no protection to clots. These patients had, in switching to the newer pain medication unwittingly took away their clot protection and the incidence of medical conditions associated with clots reappeared.
I am making no scientific claims to the above information. In my experience, however, I have noted benefits. Those diving with me have also tried and noted the same effects. The increase bleeding posed little problem. On occasion, a scratch would bleed a little longer but would eventually stop. I also noted that when loading a speargun and bracing it against a thigh or stomach, slight bruising sometimes occurred.
I currently use enteric coated aspirin to keep it "out of my stomach" longer.
Hopefully, this information is useful or at least informative. I regret that I cannot provide the actual scientific data. Perhaps one of you might be able to find it.
Regards,
Larry Stein