awap,
I answered bogdan.zivano's question by supplying him one real example of a regulator, though fitted with a manufacturer-supplied 300 Br DIN connector, was almost certainly not able to handle 300 Br tank service pressure (since it couldn't handle 4,000 psig, and only marginally handled 3,500 psig).
As to your question, I suspect the problem was due to the regulator's design. Not too much later, Scubapro began offering the "Mk 10 Plus" as a replacement to the "Mk 10." The Plus has a different piston and seat and spring and has other design differences, as well. Scubapro offered a kit to upgrade a "Mk 10" to a "[psuedo] Mk 10 Plus." I upgraded two of my three 10's to pseudo Plus's, to use, briefly, with my HP cylinders, and subsequently have experienced no more problems—at 3,500 psig. (I actually purchased Poseidon's to use with cave-filled HP cylinders shortly after I upgraded my 10's to Plus's. I use/used the Plus's for rec diving, and the Poseidon's for tech diving in cold Great Lakes water.)
I am not a certified Scubapro tech, though I service and rebuild most of my Scubapro regulators. I was told by a certified tech that the problem with the 10 is it doesn't control its intermediate pressure well at high tank service pressures. It is unstable at high tank service pressures. This tech told me that the Plus was a quick fix for this before the Mk 20 [sic] began being offered. (And then the 20 had its own issues, as you're probably aware, which is why the 25 was introduced very shortly after that!)
Safe Diving,
rx7diver