Scubapro is confused, covering their ass, or both.
In order to use Nitrox mixes richer than EAN40, a first-stage regulator needs to be oxygen-clean and built with oxygen-compatible parts (and lubricants). The second stage just doesn't matter, because it isn't exposed to HIGH-PRESSURE/high-oxygen gas.
The Scubapro regulator out of the box is oxygen-clean, and what they're trying to tell you is that if you use it with non-oxygen-clean gas, it won't be oxygen-clean anymore (true). It is false that you need an oxygen-clean regulator for any Nitrox, you only need oxygen-clean if the first stage is exposed to mixes richer than 40%. So you can ignore what Scubapro has to say about gases and arbitrarily switch between Air and Nitrox (up to 40% O2 content) without any special servicing of the regulator.
If you want to go with Oxygen contents GREATER than 40%, then the regulator needs to be used and maintained in an oxygen-clean state. It needs to be assembled with O2 clean and compatible parts, with O2 compatible lubes, and not allowed to come into contact with non-O2 clean gas. That isn't to say that it can no longer be used with air, provided the air has undergone the extra filtration to further minimize the hydrocarbons in it and is blessed as "oxygen clean air". It also isn't to say that all Nitrox is oxygen-clean either; for example, Nitrox made by a continuous flow or membrane system that feeds the EAN32 into a regulator scuba compressor isn't oxygen-clean unless it also undergoes the extra filtration (and it doesn't have to). Many fill stations only deliver oxygen-clean gasses (mine is set up that way), and many don't; you need to ask if you care.
As far as oxygen-compatible parts, a few years ago Scubapro started selling (for extra cost) an Oxygen-compatible overhaul kit for the Mk25. Prior to that, a lot of technical divers (myself included) used the regular overhaul kit with the Mk25s with pure oxygen no ill effects, but today I would have to recommend you use the Oxygen-compatible kit if you're planning on mixes over 40% O2.
Another commenter mentioned the use of silicon to prevent corrosion inside an oxygen regulator. I wouldn't recommend it. In a high-pressure oxygen environment we have another name for silicon -- FUEL.