First a clarification, most serious Canon cameras can operate in manual, TTL, or e-TTL modes. E-TTL is likely to give the best results in most Canon cameras as Canon has spent the most time developing this part of their flash algorithms. The ikelite housing will have a connector that mounts to the top of the camera where you would normally add a flash topside. When used with Ikelite DS strobes, the flash exposure will be automatically set using canon's e-TTL metering. The advantage is that metering is optimal, but the disadvantage can be fewer options in strobes and problems if there is a leak or broken wire.
The Canon housing has no connectors for strobes. However, some strobes can be used with an optical trigger (fiberoptic or slave sensor) if the internal flash is turned on. Strobes with optical sensors can be TTL or manual. The TTL strobes typically rely on matching the duration of the built-in flash (Inon calls this sTTL, but the camera should be in standard TTL mode). The G11 fires it's internal flash and stops the flash (quenching is the common term) as soon as the G11 detects enough light in the photograph. If your strobes are also flashing with the internal flash, you achieve TTL strobe metering without a wire. There are some drawbacks to this method; for example, you should block the internal G11 flash from shooting forward or you can still get backscatter. The lack of a wire or connector is considered a feature by some, as there are fewer parts to break.
If a Canon is in e-TTL mode and an optical trigger is used for strobes you can experience problems. In e-TTL, the camera will send one one or more pre-flashes to get an estimate of the needed flash duration during the actual photo. These pre-flashes can confuse optical triggers, though many have settings to try to get around this problem.
I personally use Ikelite strobes wired to a dSLR, so I don't have personal experience with the G11 or Inon strobes.