Ther is little chance for a rolloff. If you manage to drag your valve knobs along a surface long enough to close them, you would likely be dragging the back od your head as well. The risk of entanglement is the same with a manifold as with two valves/regs from independants. As the last poster noted, an isolator failure is extremely remote. Most manufacturers now use the double barrel o-ring design. With independants, if one reg fails or freeflows, you've lost all gas from that tank. With an isolated manifold, you simply close the valve on that side and you still have access to all of the gas from both tanks.