I found this interesting...
Measurement of fatigue following 18 msw dry chamber dives breathing air or enriched air nitrox
"Since the early days of compressed gas diving, air has been the principle gas employed due to its ready availability. Using EANx, bottom time can be significantly increased compared to diving at the same depth with air, without additional decompression penalty. It is extremely common for divers to claim less fatigue following a dive breathing EANx than they would expect for a similar air dive. In this study following simulated dives controlled for depth, bottom time, decompression rate, temperature, and physical exertion,
subjects blinded to breathing gas reported no subjective difference in fatigue (visual analogue scale) breathing air or EANx. In addition there was no difference in fatigue as assessed by the MFI-20 or in the psychometric tests for attention and concentration."
That said, I prefer to dive NITROX for the reason Wookie and others have pointed out. Plus this study:
Enriched Air Nitrox Breathing Reduces Venous Gas Bubbles after Simulated SCUBA Diving: A Double-Blind Cross-Over Randomized Trial is reason enough for me.