Very much down to personal experience, but I prefer the comfort of a neoprene seal over latex. I don't find I get any leaks, no matter how much I look around, and I don't find them any more bother than latex. I have neoprene wrist seals too.
Sometimes the weather in the UK can be downright lousy for the entire day, and I can get into my suit first thing in the morning and stay in it till last thing at night and not have to worry. None of my buddies who wear suits with latex seals on the neck and wrists can stay in their suits that long without having some discomfort the first thing they usually do on exiting the water and de-kitting is to get their head and arms out of the suits and leave the top hanging around their waist from the braces. Having said that, you will also find devotees of latex, so...
Horses for courses, I'm afraid.
Mark