I've read lots of things that were not true.I’ve read that 2nd stages, with their thin diaphragms, are the most susceptible to failure, but again, I cannot find the specific data.
Whatever the case, it appears that quite few deaths occur annually due to regulator failure.
As i read the fatality reports, it seems that the deaths tend more to come from panic induced by a problem, not by the problem itself.
And it is not clear that these were actually regulator failures.....as this thread has shown, there is no agreement on what that even means.
And you started by asking about first stages; now you've moved to second stages?