The logic goes that if the manifold fails, there is really not much you can do, you face complete gas loss. So that makes the case for avoiding things that could make the manifold fail. Manhandling it from opposite valves, versus the crossbar itself ... it´s an interesting discussion in "theoretical" physics that the internet can always provide (I can even see people posting data from a 1953 study) . Anyhow, I sometimes grab them by the crossbar, specially when going up and down the stairs in my apartment. And I try to grab the tanks by the outer valves most of the times, just because it´s better etiquette. The only truth might be, don´t do strange forcing stuff on an isolator valve, because that might be "the weak point" if you want to find one in a set of manifolded doubles.