Some sets require a little more work to trim out, but I've dived 5 different sets over the last 4-ish weeks, and it ain't no thang.
As to training - once you get the basics dialed in (buoyancy, trim) and have gone through 50 valve drills, can manage the gear, I'm confident I can manage the very, very unlikely blow out, failuire or buns-up situation.
The BIG thing is managing all this gas. I mean, the tanks and the gymnastics of managing them is just muscle memory and practice. Not training. I worked with an instructor, he made some minor suggestions to my current practice routine, and I'm off an running.
Managing all of this gas is where I can get into trouble. The "training" isn't for the diving, its for the dive planning. And for this, I can't recommend good training enough. I'm about to go from doing a couple of hundred sub-125 FSW dives a year to replacing probably 40 or 50 of them each year with 130 - 160 FSW. There is deco involved here. There will likely be an O2 bottle involved here.
The tollerances for planning will be much narrower for these 25% of my upcoming dives. This is the only reason I'm going for further training. Its not to actually dive the equipment - its to dive the gas.
---
Ken