I believe to some degree, the distribution is known -- I think there are definitely depth/time combinations where you can say pretty much for sure that if you do them, you will be symptomatic. And there are some where, within 99% probability, you won't be. The problem is that we are trying to define in fine a process which is only understood probabilistically, and that type of understanding is poor at defining probabilities for any individual.
It's like coronary risk factors. They're great at predicting cardiac risk likelihood in a population, and all but worthless for assessing it in individuals.