I actually had an interesting one last year. On the surface, thankfully. We were setting up a downstream Emerald dive. My doubles were assembled and checked, valves open, and upright in my truck bed. We're going over the details in the parking lot and I hear a "POP-WHOOSH" as gas starts dumping out of my doubles. I tried to shut down the right post but couldn't do it. So we isolated and tried to figure out what it was, as gas was coming out of the handwheel. Ended up being an extruded bonnet nut o ring. That was the root cause, at least. For whatever reason, the valve stem got jammed up when that happened and we had to basically let that side drain and break down the valve to close the HP seat with a flathead. Would've been bad news underwater on a straight bar manifold.
If you're concerned about this kind of valve failure underwater, consider that the isolation valve is a single point of failure for the issue you had. If the same defect your right post valve had occurs at the isolation valve then you lose all backgas quickly but can't do anything about it.
Usually this point about the isolation valve being a single point of failure is made by sidemount divers or those with independent doubles, but dismissed by the DIR divers because they think it's very unlikely to happen and so you shouldn't be concerned about it but rather prefer to have the option to save more backgas in case of a regulator failure. But you had it happen, and you are concerned about it, so just saying that the isolation valve did not eliminate your single point of failure and you rather gave a reason for independent tanks.