Warthaug
Contributor
MikeFerrara:My last post continued sort of...
In regard to genetic sequencing. Is this a reasonable (though partial) explanaition of how DNA sequencing is used?
From http://www.talkorigins.org/faqs/faq-intro-to-biology.html
Its a lot more advanced now, especially in the genomics age. But the concept is the same. Basically, if you know the rate in which mutations accumulate in certain genes, you can begin comparing those genes between organisms and start determining their genetic relation to each other, as well as how long its been since they separated into different species.
MikeFerrara:It appears that sequencing data is calibrated or scaled (in regard to time) based on assumptions originally inferred from the fossil record in order to infer time lapsed since diversion. Genetic difference is what is measured.
Not so much anymore. A lot of effort has been put into validating the genetic timeline. This is done by monitoring the rates of mutations in existing populations, as well as (when available) comparing mutations between old samples vs. the species as it exists today.
As you may image this form of record is quite complete for quickly reproducing species - bacteria on upto insects. For "higher" animals we've got less data, but the data we do have agrees 100% with both the fossil record, as well as our previous genetic estimates.
MikeFerrara:This assumes, rather than establishes, that there was a common ascestor and that there ever was ever a divergence in the first place.
Ockhams razor - simplest explanation is the most likely one. Nearly all of the genetic and fossil evidence supports the concept of common ancestry. When you see two species share a certain amount of genetic material, and you see that the parts which differ in a predictable and regular way, and the dating of this differentiation agrees quite closely with whats observed in the fossil record, common ancestry is the simplest explanation for what youve observed. After all, what is more likely, that these predictable and consistent differences occurred via changes in the same thing, or that they (plus the similarities) developed randomly, from different sources? For that matter, we observed the formation of new species which confirms it. And we've seen speciation events in everything from the simplest of bacteria and viruses, right through to complex things like plants and animals.
MikeFerrara:Going back to the study that we've been discussing I'm not sure that we can really consider DNA sequencing as being independant of stratigraphy with regard to a "time lapsed since diversion" estimation.
But it is - at least now that we have mutation rate analysis that has been determined empirically - i.e. has been measured in nature, rather then inferred through the fossil record.
Bryan