ok so first we have to understand what the balancing mechanisms do
in an unbalanced first stage, the IP is determined by the delta between the spring pressure and the tank pressure. This is less than ideal because IP determines how well the second stages function.
A balanced first stage will have a theoretically constant IP regardless of tank pressure which helps with predictability in second stage function
Second stages work exactly the same as the first stages, except instead of tank pressure, they function off of intermediate pressure. If the IP changes on an unbalanced second stage, the work of breathing will change accordingly.
I would not purchase an unbalanced first stage unless you are using it for suit inflation or other non-breathing activities. If you have unbalanced second stages, it is not significant, however the second stages have to be tuned against the first stage that they will be used with for optimal performance. For reference, all of my regulators, I believe 10 sets right now, are balanced first stages, with unbalanced second stages. I use Poseidon Jetstreams. Most all modern regulators are balanced first and balanced seconds with the exception of the low performance octo's