Since you mention that you are going to CCV, I'll add a bit of
geography and climatology to the discussion.
This is not to dissuade you from the meds, just some facts to know.
CCV is located on a
hard sand cay that
drains rainwater quickly and has
no standing water. The vegetation is constantly being
cut back by groundskeepers. This,
the South side (
windward) of the island, is constantly bathed in
prevailing breezes that come in from the ESE. The South
shore in general is
not a mosquito friendly place, and at CCV they have no foot-hold. After over some 70+ weeks of us staying there, I have noticed a mosquito only once. It was not the kind that carries malaria specifically. Maybe I'm just a lucky kind of guy. Or blind. They got to be there, but that is just my experience.
The overwhelming numerical majority of visitors to Roatan are in West End and North Side (as in AKR above mentioned). This North side of the island sits in the lee (the shadow) of any prevailing winds, the wooded vegetation is left standing (because of the non-farming land nature of that zone) and there are numerous creeks, rain barrels, and standing pools of water.
The North is an ideal location for insects of every type and this has always been my experience in visiting.
The CDC advice is an arguably conservative, broad-brush treatment, and in no way am I arguing. Just as there is less exposure if you are indoors, then irrefutably there is lessened risk of exposure in environments where mosquitos find no home. Pretty simple math.

As soon as I get off the plane, I smear myself with a tube of DEET cream (it passes thru TSA). Look around the airport environ itself. There is ditched standing water everywhere. I have gotten eaten alive at the airport. More for the damned sand flies, but at CCV we spray up with DEET a lot.
This is a highly charged and emotional subject (due in part to
the Jenny McCarthy School of Medicine, University of the Googles) but seeking reassurance on a social media message board is indicative of the problem. You'll probably get a larger volume of information from

, if volume is what you were seeking.
I do rather enjoy the Malaria pills because when I burp, which they make me do, I am reminded of a Gin and Tonic, of which I am rather fond.