The S550 and S600 are essentially identical with the only difference being the S600's adjustment knob.
The S600 and the G250 are also essentially identical with the only difference being a larger case and diaphragm on the G250.
I personally think there are some real engineering advantages to the larger diaphragm used in the G250 given the forces and leverages involved in operating the demand valve in the second stage. Theoretically, a G250 can be fine tuned to breathe a little easier due to the larger diaphragm but both the S600 and G250 come adjusted to breathe a lot harder than they have to from the factory (to comply with CE norms).
I have also never seen any practical advantage to having a smaller second stage and feel that most of the perceived need by divers to have a smaller second stage is mostly the effect of marketing hype. A larger second stage is slightly heavier, but it also displaces more water so the net in water weight difference is zero and a smaller second offers no real benefit in terms of preventing jaw fatigue.
Proper mouth piece design and selection and proper LP hose lenght have a LOT more to do with preventing jaw fatigue, TMJ, etc.