I am a dm for a shop that sells Scubapro, and I get it cheap. I have 2 mk20's, 2 mk16's, 2 mk2's. For second stages, I have a G500, 3 R380's, 1 G250, and 2 190's.
There is no difference in the breathing of the Mk20 vs. the Mk16, in my opinion.
There is no difference in the breathing of the G500, the R380, and the 250. I was surprised at how much I liked the 250 on my one dive with it last weekend; it was sweet. Might be my new favorite.
Size doesn't appear to matter. I haven't had any of the big ones til recently, but they seemed just fine to me.
They all freeflow if you adjust them too light, but they can be detuned on a truck tailgate in about 2 minutes with a 1/4" wrench, a 1/4" nutdriver (better) or a pair of needle nose pliers. I like them detuned a bit so they don't free flow; I'm not that sensitive to cracking pressure.
If money was a consideration, I'd buy the Mk16 and the G250 with a G250 second or a 190 second.
If money was not a consideration, I'd buy the Mk25 (like the Mk20, actually, except they changed the adjustment method from shims to a screw, which they didn't really need to do; it's just a gimmick in my opinion.) and the G600, just because I don't have one yet. However, I bet the R380 is just as good except it doesn't have the little knob to fiddle with.
Haven't used the Mk2's and 190's yet, but I expect they will be just fine. I think they are kind of the Chevy 6 cylinder stick shift kind of regs.
The actual bottom line is, you'll be very, very happy with any of the Scubapros and probably with any of the recommended APEX regs.
I'm going to buy an APEX setup this year just to see if all you clowns are right about how great they are. I bet they are no better, but I'll be the first to eat my words if I'm wrong. I ain't that proud. I pay retail for Halcyon wings when I can get DiveRite wholesale, for example.