Hello Saturation:
Activity and Nucleation
There are considerable data linking musculoskeletal activity and DCS. What is not demonstrable is that nucleation is the root cause. That is my extension of ideas of early researchers such as Harvey and Dean. The difference is that these individuals proposed nuclei stabilization in, e.g., cell wall junctions. These were not really thought to be stable. It is my opinion that we are dealing with a constantly renewing distribution of nuclei, generated by musculoskeletal activity. This makes sense based on work in physical systems but the direct sampling of micronuclei from intracellular fluids is not possible. Thus we simply demonstrate the presence of nuclei by depressurization, but this is conjectural (but logical).
I believe that we are dealing with what hydrodynamic engineers refer to as free stream nuclei as contrasted with wall nuclei (Harveys idea).
Resting Animals
Many researchers have noted that anesthetized animals are very resistant to gas bubble formation during decompression. This is probably the result of a reduction in hydrodynamic cavitation.
At NASA we have used a reduction of activity in the lower body to simulate the weightlessness of space. Decompression in space appears to be associated with a reduced level of DCS. This lower body adynamia has been described in papers and reports, not all of which are easy to obtain. Other papers are in preparation.
Other Correlations
Some of this relationship of activity and DCS was observed during WW II and appears in Fultons book Decompression Sickness. Activities are quantified in terms of distance moved or in oxygen uptake.
Dr Deco :doctor:
Readers, please note the next class in Decompression Physiology :grad:
http://wrigley.usc.edu/hyperbaric/advdeco.htm
References
Powell, MR, KV Kumar, J Waligora. Joint pain and Doppler-detectable bubbles in altitude (hypobaric) decompression. Undersea Biomed. Res., 19 (Suppl.), 55, (1992).
Powell, MR, J Waligora, W Norfleet. Decompression in simulated microgravity; bed rest and its influence on stress-assisted nucleation. Undersea Biomed. Res., 19 (Suppl.), 54, (1992).
Powell, MR, J Waligora, W Norfleet, KV Kumar. Project ARGO - Gas Phase Formation In Simulated Microgravity. NASA Tech Memorandum 104762, pp. 87, (1993).
Waligora, J, Powell, MR, and W Norfleet. The abaroferic hypothesis: a mechanism for the reduction of decompression sickness in microgravity, Aviat. Space Environ. Med., 64, 421, (1993).
Powell, MR, W. Norfleet, J Waligora, KV Kumar, R. Robinson, and B. D. Butler. Modifications of physiological processes concerning extravehicular activity in microgravity. Inter. Cong. Environ. Systems, SAE Technical Paper Series, (1994).
Powell, MR, J Waligora, KV Kumar. Hypobaric decompression in simulated null gravity; a model using chair-rest adynamia. Undersea Biomed. Res., 22 (Suppl), 67, (1995).
Powell, MR, J Waligora, and KV Kumar. Decompression gas phase formation in simulated null gravity. 25th International Conference on Environmental Systems. SAE Technical Paper Series 951590, (1995).
Loftin K.C., J. Conkin, MR Powell. Modeling the effects of exercise during 100% oxygen prebreathe on the risk of hypobaric decompression sickness. Aviat. Space and Environ. Med. 68, 199 - 204, (1997).
Srinivasan, S, and MR Powell. The effects of surface tension on bubble volume changes using a mathematical model. Undersea Hyperbaric Med., 24 (Suppl.): 25, (1997).
Powell, M.R. An algorithm for the calculation of the effect of adynamia on altitude decompression risk. Undersea Hyperbaric Med., 26 (Suppl), 56, (1999).
Conkin J, Powell MR. Lower body adynamia as a factor to reduce the risk of hypobaric decompression sickness. Aviat. Space Environ. Med. 72, 202 214, (2001)
Dervay JP, Powell MR, Butler B, Fife CE. The effect of exercise and rest duration on the generation of venous gas bubbles at altitude. Aviat Space Environ Med. 2002;73(1):22-7.