No need to wait to dive as long as you are well hydrated and rested. On Bonaire you generally have to get an orientation and do a checkout shore dive first, no big deal but if you are diving someplace with a fixed schedule for that it may play into what you do.
As far as 48 hours before flying, I guess it never hurts to be really conservative but I personally would be more inclined to take one or two breaks during a 2 week trip, either skip a day or maybe part of a day, like just do a couple dives in the morning then play tourist until the next day.
(How many dives do you mean by "alot" - your profile says you've been diving on vacation every year for 9 years and have 50-100 dives. Unless that's wrong or you've greatly upped your dive frequency lately, it doesn't sound like you're soaking up that much nitrogen.)