If you are doing a couple relatively easy dives in a dive day, I am sure you would not notice a difference.
I'm of the belief that much of the unnatural fatigue experienced by divers stems from decompression stress.
In that respect, it's important to differentiate between 'easy' and 'clean' dives.
I notice the most decompression stress after completing shallow (<12m) skills dives, especially when there is ascent and buoyancy training involving multiple small (+/-4m) ascents or depth variations (relatively sawtooth profiles, given the shallow depth).
After these dives, I can feel very exhausted... Fall asleep on the boat and/or couch mode. Yet after repetitive deep or decompression dives (using nitrox, multiple off-gassing stops and ascent/deco gasses), I usually feel fresh as a daisy and full of vitality.
Like many technical divers, I pay close attention to my post-dive vitality, as a means to determine optimal deco algorithm and ascent protocols across a range of dive parameters.
For many recreational divers, 'easy' dives can still provoke significant decompression stress through sawtooth profiles, imprecise ascent speeds and minimal or no stops before surfacing.
Nitrox reduces decompression stress, where it might occur. However, if the diver isn't creating significant decompression stress in the first place, no difference in post-dive vitality will be noticed.
Hence, the experienced divers on thread, who do 'clean' dives will notice little/no variation in post-dive vitality.
Less experienced or more aggressive divers, doing 'dirty' profiles and ascents might notice (and benefit from) the impact of nitrox in reducing decompression stress during the ascent phase of the dive.